Clinical presentation and outcome of colorectal cancer in HIV-positive patients: a clinical case-control study
| Autor: | Berretta, M, Cappellani, A, Di Benedetto, F, Lleshi, A, Talamini, R, Canzonieri, V, Zanet, E, Bearz, A, Nasti, G, Lacchin, T, Berretta, S, Fisichella, R, Balestreri, L, Torresin, A, Izzi, I, Ortolani, P, M lanzafame, Tirelli U., Guaraldi, G, Giacomazzi, D, Malincarne, L, Nunnari, G |
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| Přispěvatelé: | Berretta, M, Cappellani, A, Di Benedetto, F, Lleshi, A, Talamini, R, Canzonieri, V, Zanet, E, Bearz, A, Nasti, G, Lacchin, T, Berretta, S, Fisichella, R, Balestreri, L, Torresin, A, Izzi, I, Ortolani, P, Tirelli, U |
| Jazyk: | němčina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Colorectal cancer Adult Case-Control Studies Colorectal Neoplasms mortality Comorbidity Female HIV Infections mortality Humans Italy epidemiology Male Middle Aged Outcome Assessment (Health Care) Prevalence Risk Assessment Risk Factors Survival Analysis Survival Rate folinic acid MEDLINE HIV Infections Comorbidity Risk Assessment fluorouracil Outcome Assessment (Health Care) Risk Factors Internal medicine Outcome Assessment Health Care Prevalence irinotecan medicine Humans Survival rate Survival analysis business.industry Case-control study virus diseases Hematology General Medicine Middle Aged medicine.disease mortality Survival Analysis Survival Rate Italy Case-Control Studies Female epidemiology Presentation (obstetrics) Colorectal Neoplasms Risk assessment business |
| Popis: | Background: Data on colorectal cancer (CRC) in HIV-positive patients are limited. The study objective was to investigate and compare clinical presentation and outcome between HIV-positive and HIV-negative CRC patients. Patients and Methods: Between September 1985 and November 2003 we identified 27 cases of HIV-positive CRC patients from the cancer registry database-Italian Cooperative Group AIDS and Tumours (GICAT); the clinical presentation/outcome information was retrieved. Each HIV-positive patient from our institution was randomly matched (ratio 1: 2) with HIV-negative patients (54 controls) based on age, sex, and year of diagnosis in the same time period. Differences in clinical presentation, treatment, and overall survival were assessed. Results: Of 1130 HIV-negative CRC patients, 54 were identified and matched with 27 HIV-positive patients. Compared with the HIV-negative patients, the HIV-positive patients had a higher risk of lower performance status (PS: >= 2) (odds ratio (OR) = 14.4; 95% confidence interval (CI): 3.6-57.7), a higher risk of unfavorable Dukes' stage (D) (OR = 4.9; 95% CI: 1.8-13.5), and a higher risk of poor grading (G3-G4) (OR = 5.0; 95% CI: 1.9-13.4). Median overall follow-up was 27 months (range: 2-212). At multivariate analysis, the only characteristics that significantly reduced the survival of the CRC patients were: HIV-positive status (hazard ratio (HR): 2.4; 95% CI: 1.1-5.2) and Dukes' stage D (HR: 3.7; 95% CI: 1.9-7.1). Conclusion: Our data show that HIV-positive CRC patients compared to HIV-negative patients have a poorer PS, an unfavorable Dukes' stage, higher grading and shorter survival. |
| Databáze: | OpenAIRE |
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