Building a Population Representative Pediatric Biobank: Lessons Learned From the Greater Cincinnati Childhood Cohort
| Autor: | Liza Bronner Murrison, Lisa J. Martin, Melinda Butsch Kovacic |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Gerontology
medicine.medical_specialty Adolescent Population Participatory action research White People Cohort Studies 03 medical and health sciences 0302 clinical medicine children Epidemiology medicine Humans genetics 030212 general & internal medicine Child education Disease burden Biological Specimen Banks 030304 developmental biology 0303 health sciences education.field_of_study research business.industry lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 Hispanic or Latino Brief Research Report Biobank Black or African American Child Preschool Cohort community epidemiology Public Health Sample collection business Strengths and weaknesses |
| Zdroj: | Frontiers in Public Health Frontiers in Public Health, Vol 8 (2021) |
| ISSN: | 2296-2565 |
| DOI: | 10.3389/fpubh.2020.535116 |
| Popis: | Background: Biobanks can accelerate research by providing researchers with samples and data. However, hospital-based recruitment as a source for controls may create bias as who comes to the hospital may be different from the broader population.Methods: In an effort to broadly improve the quality of research studies and reduce costs and challenges associated with recruitment and sample collection, a group of diverse researchers at Cincinnati Children's Hospital Medical Center led an institution-supported initiative to create a population representative pediatric “Greater Cincinnati Childhood Cohort (GCC).” Participants completed a detailed survey, underwent a brief physician-led physical exam, and provided blood, urine, and hair samples. DNA underwent high-throughput genotyping.Results: In total, 1,020 children ages 3–18 years living in the 7 county Greater Cincinnati Metropolitan region were recruited. Racial composition of the cohort was 84% non-Hispanic white, 15% non-Hispanic black, and 2% other race or Hispanic. Participants exhibited marked demographic and disease burden differences by race. Overall, the cohort was broadly used resulting in publications, grants and patents; yet, it did not meet the needs of all potential researchers.Conclusions: Learning from both the strengths and weaknesses, we propose leveraging a community-based participatory research framework for future broad use biobanking efforts. |
| Databáze: | OpenAIRE |
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