Preparation and characterization of Tegafur magnetic thermosensitive liposomes
Autor: | Yang-de Zhang, Liu Xingyan, Xiao-li Wang, Zhao-wu Zeng, Nianfeng Li, Wei-hua Zhou |
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Rok vydání: | 2009 |
Předmět: |
Antimetabolites
Antineoplastic Liposome Chromatography Materials science Magnetism Coprecipitation Chemistry Pharmaceutical Temperature Pharmaceutical Science Thermosensitive liposomes General Medicine equipment and supplies Evaporation (deposition) Tegafur Magnetics Liposomes medicine Chemical Precipitation Particle size Particle Size human activities Nuclear chemistry medicine.drug Superparamagnetism |
Zdroj: | Pharmaceutical Development and Technology. 14:350-357 |
ISSN: | 1097-9867 1083-7450 |
DOI: | 10.1080/10837450802647300 |
Popis: | The purpose was to study the preparation and properties of tegafur magnetic thermosensitive liposomes. The method was to employ an improved chemical coprecipitation method for preparing nano-magnetic particles and a reverse-phase evaporation and ultrasonic method for preparing tegafur magnetic thermosensitive liposomes. The results showed that tegafur magnetic thermosensitive liposomes were prepared successfully. They had comparatively strong magnetism and superparamagnetism, and their temperature showed a linear positive correlation with dosages and the field strength under a current value. The conclusion was that tegafur magnetic thermosensitive liposomes with comparatively small particle size, superparamagnetism and comparatively strong magnetism were prepared successfully. |
Databáze: | OpenAIRE |
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