| Autor: |
Eduardo B. Mass, Carolina A. de Lima, Marcelo G. M. D’Oca, Juliana M. Sciani, Giovanna B. Longato, Dennis Russowsky |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Drugs and Drug Candidates; Volume 1; Issue 1; Pages: 3-21 |
| ISSN: |
2813-2998 |
| Popis: |
Designed Chalcone-Dihydropyrimidinone hybrid compounds were synthesized expeditiously. The hybridization was performed through the Copper-catalyzed Alkyne-Azide Cycloaddition (CuAAC) from the propargyloxy chalcones and azido-dihydropyrimidinones. The hybrid products were prepared in five steps with a 30–48% overall yield. Most of the compounds showed selective cytotoxicity and lower IC50 values ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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