Acute and Sub-Chronic Toxicity of Aqueous Extracts ofChenopodium ambrosioidesLeaves in Rats
| Autor: | Carlos Campos Câmara, José Domingues Fontenele Neto, Raimundo Neilson de Lima Amorim, Marcel Gianni C da Silva, Benito Soto-Blanco |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Medicine (miscellaneous) Aspartate transaminase Pharmacology chemistry.chemical_compound Animals Urea Aspartate Aminotransferases Rats Wistar Creatinine Nutrition and Dietetics Aqueous solution biology Plant Extracts Chenopodium ambrosioides Alanine Transaminase Acute toxicity Plant Leaves Liver Alanine transaminase chemistry Toxicity biology.protein |
| Zdroj: | Journal of Medicinal Food. 17:979-984 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2013.0134 |
| Popis: | The present study aimed to evaluate the toxicity of aqueous extract of Chenopodium ambrosioides leaves. To measure acute toxicity, rats were administered 0, 0.3, 1.0, or 3.0 g/kg of aqueous extract from C. ambrosioides leaves by gavage. To analyze sub-chronic toxicity, rats were treated by oral gavage for 15 consecutive days with 0, 0.3, or 1.0 g/kg of extract of C. ambrosioides leaves. No animals from either trial exhibited any signs of toxicity. In the acute study, the highest dose of the extract led to an increase in the serum activities of alanine transaminase (ALT) and aspartate transaminase (AST) and a decrease in the serum levels of urea. In the sub-chronic test, rats treated with 1.0 g/kg for 15 days exhibited increased serum ALT activity and creatinine levels and mild cytoplasmic vacuolation of hepatocytes. The results indicate that aqueous extract from C. ambrosioides leaves produce slight hepatotoxic lesions in rats. |
| Databáze: | OpenAIRE |
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