Liquid Biopsy in Non-Small Cell Lung Cancer
| Autor: | Raquel Campos, Mónica Garzón, Xavier Gonzalez, Miguel Angel Molina-Vila, Maria-de-los-Llanos Gil, Rafael Rosell, Clara Mayo-de-las-Casas, Ariadna Balada, Daniela Morales-Espinosa, Ana Pérez-Rosado, Maria José Catalán, Ana Giménez-Capitán, Núria Jordana-Ariza, Cristina Aguado, Cristina Teixidó, Santiago Viteri, Maria Gonzalez-Cao, Sergi Villatoro, Jordi Bertran-Alamillo, Alejandro Martinez-Bueno, Niki Karachaliou, Beatriz García-Peláez |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pathology Mini Review exosomes gene fusions 03 medical and health sciences 0302 clinical medicine Circulating tumor cell Internal medicine Medicine Routine clinical practice Liquid biopsy Lung cancer ctRNA business.industry Cancer General Medicine ctDNA medicine.disease mutations tumor-educated platelets lung cancer 030104 developmental biology Circulating free DNA 030220 oncology & carcinogenesis Non small cell CTCs business |
| Zdroj: | Frontiers in Medicine |
| ISSN: | 2296-858X |
| DOI: | 10.3389/fmed.2016.00069 |
| Popis: | Liquid biopsy analyses are already incorporated in the routine clinical practice in many hospitals and oncology departments worldwide, improving the selection of treatments and monitoring of lung cancer patients. Although they have not yet reached its full potential, liquid biopsy-based tests will soon be as widespread as “standard” biopsies and imaging techniques, offering invaluable diagnostic, prognostic, and predictive information. This review summarizes the techniques available for the isolation and analysis of circulating free DNA and RNA, exosomes, tumor-educated platelets, and circulating tumor cells from the blood of cancer patients, presents the methodological challenges associated with each of these materials, and discusses the clinical applications of liquid biopsy testing in lung cancer. |
| Databáze: | OpenAIRE |
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