TRPV6 as A Target for Cancer Therapy
| Autor: | John M. Stewart |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
TRPV6 chemistry.chemical_element Endogeny Review Calcium 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine pancreas medicine cancer Ion channel breast Calcium metabolism calcium prostate Cancer medicine.disease Phenotype Cell biology 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Two decades ago a class of ion channels, hitherto unsuspected, was discovered. In mammals these Transient Receptor Potential channels (TRPs) have not only expanded in number (to 26 functional channels) but also expanded the view of our interface with the physical and chemical environment. Some are heat and cold sensors while others monitor endogenous and/or exogenous chemical signals. Some TRP channels monitor osmotic potential, and others measure cell movement, stretching, and fluid flow. Many TRP channels are major players in nociception and integration of pain signals. One member of the vanilloid sub-family of channels is TRPV6. This channel is highly selective for divalent cations, particularly calcium, and plays a part in general whole-body calcium homeostasis, capturing calcium in the gut from the diet. TRPV6 can be greatly elevated in a number of cancers deriving from epithelia and considerable study has been made of its role in the cancer phenotype where calcium control is dysfunctional. This review compiles and updates recent published work on TRPV6 as a promising drug target in a number of cancers including those afflicting breast, ovarian, prostate and pancreatic tissues. |
| Databáze: | OpenAIRE |
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