Overcoming the drug resistance in breast cancer cells by rational design of efficient glutathione S-transferase inhibitors
| Autor: | Hui Chuan Chang, Wing See Lam, Kung-Cheng Liu, Sachin S. Shivatare, Ya Ching Jen, Yu-Ting Hsu, Wen-Shan Li, Shu-Chuan Jao, Chie-Hong Wang |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Models
Molecular Activity profile biology Organic Chemistry Rational design Breast Neoplasms Drug resistance Pharmacology Biochemistry chemistry.chemical_compound Structure-Activity Relationship Glutathione S-transferase chemistry Chemotherapy Drugs Drug Resistance Neoplasm Drug Design biology.protein Humans Female Breast cancer cells Bioisostere Physical and Theoretical Chemistry Glutathione Transferase |
| Zdroj: | Organic letters. 12(1) |
| ISSN: | 1523-7052 |
| Popis: | A new type of competitive human GST inhibitors has been developed via the bioisostere and structure activity profile strategies; we report their discovery, preparation, inhibitory activity, and synergetic effect in combination with chemotherapy drugs against breast cancer cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|