α-Methylene and glycidic acid analogs of IPPA as potential myocardial imaging agents
| Autor: | D.A. Bakan, M.K. Ruyan, R.W.S. Skinner, C. Newman, R.E. Counsell, Milton D. Gross |
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| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
Biodistribution Pentadecanoic acid Scintigraphy Chemical synthesis Rats Sprague-Dawley chemistry.chemical_compound Animals Medicine Tissue Distribution Radiology Nuclear Medicine and imaging Methylene Radionuclide Imaging Lagomorpha biology medicine.diagnostic_test Iodobenzenes business.industry Radiochemistry Heart biology.organism_classification Myocardial imaging Rats Glycidic acid chemistry Epoxy Compounds Molecular Medicine Female Rabbits Propionates business Nuclear medicine |
| Zdroj: | Nuclear Medicine and Biology. 22:95-103 |
| ISSN: | 0969-8051 |
| Popis: | Using organozinc cross-coupling reactions, two radiolabeled analogs of 15-(p-iodophenyl) pentadecanoic acid (IPPA) have been designed and synthesized as potential scintigraphic imaging agents for the heart. Both 15-(4-iodophenyl)-tridecylglycidic acid and 15-(4-iodophenyl)-2-methylene pentadecanoic acid were synthesized and radioiodinated. In tissue biodistribution studies in rats, only the alpha-methylene derivative of IPPA displayed a consistently higher heart to blood ratio and a substantially lower degree of thyroid accumulation than did IPPA alone. With respect to a scintigraphic imaging efficacy, the alpha-methylene analog of IPPA and IPPA itself showed essentially equivalent cardiac imaging profiles in rabbits, with a slight extension in imaging time for the alpha-methylene analog of IPPA. |
| Databáze: | OpenAIRE |
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