Local staging of sigmoid colon cancer using MRI
Autor: | Claus Dam, Anders Jakobsen, Lars Henrik Jensen, Hans B Rahr, Søren Rafael Rafaelsen, Jan Lindebjerg |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
diffusion-weighted imaging (DWI)
medicine.medical_specialty magnetic resonance imaging (MRI) Colorectal cancer business.industry Colonic neoplasms Research Diagnostic accuracy General Medicine medicine.disease radiology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Sigmoid colon cancer 030220 oncology & carcinogenesis Radiological weapon Journal Article medicine Radiology business |
Zdroj: | Acta Radiologica Open Dam, C, Lindebjerg, J, Jakobsen, A, Jensen, L H, Rahr, H & Rafaelsen, S R 2017, ' Local staging of sigmoid colon cancer using MRI ', Acta Radiologica Open, vol. 6, no. 7, pp. 1-6 . https://doi.org/10.1177/2058460117720957 |
ISSN: | 2058-4601 |
Popis: | Background An accurate radiological staging of colon cancer is crucial to select patients who may benefit from neoadjuvant chemotherapy. Purpose To evaluate the diagnostic accuracy of preoperative magnetic resonance imaging (MRI) in identifying locally advanced sigmoid colon cancer, poor prognostic factors, and the inter-observer variation of the tumor apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI). Material and Methods Using 1.5 T MRI with high resolution T2-weighted (T2W) imaging, DWI, and no contrast enhancement, 35 patients with sigmoid colon cancer were assessed. T-stage, N-stage, extramural vascular invasion (EMVI), and ADC values of the tumors were assessed and blindly compared by two observers using postoperative histopathological examination as the gold standard. Early tumors were defined as T1 to T3ab, and advanced tumors as T3cd or T4. Results The accuracy of the two radiologists in staging early versus advanced tumors, N-stage, and identification of EMVI was 94%/89%, 60%/66%, and 77%/60% with an inter-observer agreement of к = 0.86 (95% confidence interval [CI] = 0.67–1.00), к = 0.64 (95% CI = 0.39–0.90), and к = 0.52 (95% CI = 0.23–0.80). All the measured mean ADC values were below 1.0 × 10−3 mm2/s with an intra-class correlation coefficient in T3cd–T4 tumors of 0.85. Conclusion Preoperative MRI can identify locally advanced sigmoid colon cancer and has potential as the imaging of choice to select patients for neoadjuvant chemotherapy. Initial experience with ADC measurement was achieved with an excellent inter-observer agreement in advanced tumors. |
Databáze: | OpenAIRE |
Externí odkaz: |