Fasting plasma carotenoids concentrations in Crohn’s and pancreatic cancer patients compared to control subjects

Autor: G. Le Moël, V. Fayol, H. Faure, J. Drai, M. Laromiguière, Patrick Borel, C. Galabert
Přispěvatelé: Centre Hospitalier Universitaire de Lyon, Nutriments Lipidiques et Prévention des Maladies Métaboliques, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de biologie intégrée, CHU Grenoble-Hôpital Michallon, Hôpital Renée Sabran, Partenaires INRAE, French Society for Vitamins and Biofactors, Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire Analyses Médicale, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université de la Méditerranée - Aix-Marseille 2
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Male
030213 general clinical medicine
Pancreatic disease
Malabsorption
Endocrinology
Diabetes and Metabolism

LYCOPENE
Medicine (miscellaneous)
Intestinal absorption
0302 clinical medicine
Crohn Disease
Surveys and Questionnaires
CAROTENOIDS
ZEAXANTHIN
Carotenoid
chemistry.chemical_classification
BETA-CRYPTOXANTHIN
Sex Characteristics
0303 health sciences
Crohn's disease
Nutrition and Dietetics
ALPHA-CAROTENE
food and beverages
General Medicine
Ileitis
Middle Aged
CANCER
3. Good health
medicine.anatomical_structure
Digestion
Female
Pancreas
Adult
medicine.medical_specialty
Biology
03 medical and health sciences
INTESTINAL ABSORPTION
beta-Carotene
Internal medicine
Pancreatic cancer
medicine
Humans
Aged
030304 developmental biology
BETA-CAROTENE
medicine.disease
ABSORPTION INTESTINALE
Diet
Pancreatic Neoplasms
Endocrinology
chemistry
LUTEIN
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Biomarkers
Zdroj: International Journal for Vitamin and Nutrition Research
International Journal for Vitamin and Nutrition Research, Hogrefe, 2009, pp.87-94. ⟨10.1024/0300-9831.79.2.87⟩
ISSN: 0300-9831
DOI: 10.1024/0300-9831.79.2.87⟩
Popis: International audience; Carotenoids are colored molecules that are widespread in the plant kingdom, but animals cannot synthesize them. Carotenes are long, apolar molecules which require fully functioning digestive processes to be absorbed properly. Hence they could be interesting markers of intestinal absorption and digestion. Indeed, only few tests are available to assess these processes and only the D-xylose tolerance test is routinely used. However D-xylose is a sugar that tests only the absorption of water-soluble compounds and it only tests duodenal absorption. In this study, we have evaluated carotenoids as markers of digestion and absorption. We compared fasting plasma carotenoids concentrations in 21 control subjects, 20 patients with Crohn’s disease, and 18 patients with pancreatic cancer. Crohn’s disease alters intestinal absorption while pancreatic cancer decreases pancreatic enzyme secretion thus impairing digestion. Results show that all carotenoids are significantly lower in Crohn’s and cancer patients as compared to control subjects and the multifactorial analysis shows that this decrease is mostly independent of dietary intake. Interestingly, maldigestion as seen in pancreatic cancer more strongly influences plasma lutein and lycopene concentrations while malabsorption in Crohn’s disease acts on other carotenoids. Thus carotenoids could be interesting alternatives for testing and following patients that are suspected of having malabsorption or maldigestion syndromes
Databáze: OpenAIRE