The new nitric oxide donor 2-nitrate-1,3-dibuthoxypropan alters autonomic function in spontaneously hypertensive rats
| Autor: | Maria S. França-Silva, Petrônio Filgueiras de Athayde-Filho, Matheus M.O. Monteiro, Valdir A. Braga, Thyago M. Queiroz, Alexsandro Fernandes Dos Santos |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Atropine
Male Bradycardia medicine.medical_specialty medicine.medical_treatment Clinical Neurology Blood Pressure Vagotomy Rats Inbred WKY Nitric oxide Propane chemistry.chemical_compound Cellular and Molecular Neuroscience Heart Rate Rats Inbred SHR Internal medicine Heart rate medicine Animals Nitric Oxide Donors cardiovascular diseases Enzyme Inhibitors Wakefulness Autonomic function Analysis of Variance Nitrates Endocrine and Autonomic Systems Parasympatholytics Rats Methylene Blue Endocrinology medicine.anatomical_structure Blood pressure chemistry Hypertension cardiovascular system Hexamethonium Neurology (clinical) medicine.symptom medicine.drug Artery circulatory and respiratory physiology |
| Zdroj: | Autonomic Neuroscience. 171(1-2):28-35 |
| ISSN: | 1566-0702 |
| DOI: | 10.1016/j.autneu.2012.10.002 |
| Popis: | Previously, we found that the nitrate synthesized from glycerin, 2-nitrate-1,3-dibuthoxypropan (NDBP), increased NO levels in rat aortic smooth muscle cells, inducing vasorelaxation in mesenteric artery. However, its effects on blood pressure and heart rate as well as on autonomic function were not investigated. This study evaluated the action of NDBP on these cardiovascular parameters in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. We found that NDBP causes a biphasic response: hypotension and bradycardia followed by hypertension and tachycardia in WKY and SHR rats. Atropine (2mg/kg) blunted the hypotension induced by NDBP (15 mg/kg) in WKY and SHR (-75 ± 9 vs -12 ± 3 mmHg, n=6; -101 ± 6 vs -7 ± 2 bpm, n=6; respectively, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect