Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency
| Autor: | L L Ulfers, J J Corrigan |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Prothrombin level Medicine (miscellaneous) Antigen Internal medicine Vitamin K deficiency medicine Animals Humans Vitamin E Blood Coagulation Prothrombin time Nutrition and Dietetics medicine.diagnostic_test business.industry Warfarin medicine.disease Rats Endocrinology Coagulation Factor II Activity Prothrombin Vitamin K Deficiency business medicine.drug |
| Zdroj: | The American journal of clinical nutrition. 34(9) |
| ISSN: | 0002-9165 |
| Popis: | Rats rendered lightly vitamin K deficient with warfarin (0.01 mg/100 g, IP) and given the equivalent of 1000 units of vitamin E/kg IM for 7 days, showed a marked reduction in functional factor II activity, but normal factor II levels using Echis venom on coagulation analysis. In 12 humans receiving warfarin, vitamin E was administered in doses of 100 or 400 units/day orally for 4 wk. The results in these patients showed no significant change in the prothrombin time, factor II coagulant activity, or factor II antigen (by electroimmunoassay). However, by using a ratio of factor II coagulant activity to immunoreactive protein, significant reduction was observed when compared to pretreatment ratios. These data suggest that vitamin E acts at the step mediated by vitamin K and not in the synthesis of the factor II precursor. Although the administration of high doses of vitamin E in animals, and possibly humans, with vitamin K deficiency potentiates the vitamin K deficiency, this effect is not clinically obvious with 400 IU/day or less. |
| Databáze: | OpenAIRE |
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