The development of a model of fatigue in neuromuscular disorders: a longitudinal study

Autor: Baziel G.M. van Engelen, Joke S. Kalkman, Machiel J. Zwarts, Gijs Bleijenberg, M.L. Schillings
Rok vydání: 2007
Předmět:
Adult
Male
Sleep Wake Disorders
medicine.medical_specialty
Longitudinal study
Statistics as Topic
Pain
Physical exercise
Neurological disorder
Models
Psychological
Motor Activity
Neuropsychological Tests
Myotonic dystrophy
Developmental psychology
Quality of Care [ONCOL 4]
Physical medicine and rehabilitation
Charcot-Marie-Tooth Disease
Risk Factors
Sickness Impact Profile
Activities of Daily Living
Effective Primary Care and Public Health [EBP 3]
medicine
Perception and Action [DCN 1]
Humans
Myotonic Dystrophy
Facioscapulohumeral muscular dystrophy
Muscle Strength
Young adult
Fatigue
Human Movement & Fatigue [NCEBP 10]
Depressive Disorder
Sleep disorder
Sick Role
Psychological determinants of chronic illness [NCEBP 8]
Middle Aged
medicine.disease
Muscular Dystrophy
Facioscapulohumeral
Neuromuscular development and genetic disorders [UMCN 3.1]
Psychiatry and Mental health
Clinical Psychology
Female
Determinants of Health and Disease [EBP 1]
Microbial pathogenesis and host defense [UMCN 4.1]
Psychology
Hereditary motor and sensory neuropathy
Functional Neurogenomics [DCN 2]
Zdroj: Journal of Psychosomatic Research, 62, 5, pp. 571-9
Journal of Psychosomatic Research, 62, 571-9
ISSN: 0022-3999
Popis: Contains fulltext : 52676.pdf (Publisher’s version ) (Closed access) BACKGROUND: Severe fatigue is reported by the majority of patients with three relatively common types of neuromuscular disorders. OBJECTIVE: This study aimed to identify predictors of fatigue in a longitudinal study and to develop a model of fatigue in patients with three neuromuscular disorders. METHODS: One hundred ninety-eight patients [60 facioscapulohumeral muscular dystrophy (FSHD), 70 adult-onset myotonic dystrophy (MD), and 68 hereditary motor and sensory neuropathy type I (HMSN-I) patients] were studied twice during an 18-month period. Fatigue severity was assessed by the Checklist Individual Strength. A multidimensional assessment method was used, including self-report questionnaires, a daily Self-Observation List, and physical activity (actometer). Muscle strength was determined using the Medical Research Council scale. Structural equation modeling was used to develop and test a model of factors contributing to the persistence of experienced fatigue. RESULTS: Muscle strength, self-reported physical activity, sleep disturbances, and pain at baseline contributed directly or indirectly to fatigue and impairment at follow-up. Lower muscle strength contributed to lower levels of physical activity, which, in turn, contributed to fatigue severity. The model showed excellent fit for the whole group of neuromuscular disorders. In FSHD, pain also contributed to physical activity. A model with the actometer as measurement for actual physical activity instead of self-report showed an excellent model fit in FSHD and HMSN but an insufficient fit in MD. CONCLUSION: The model of perpetuating factors for fatigue in FSHD and HMSN is different from the model in MD. The main difference is in physical (in)activity. These differences have implications for interventions based on these models.
Databáze: OpenAIRE
Externí odkaz: