Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex
| Autor: | Qian Li, Tieqiao Wen, Jieyun Shi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neurology Physiology Glutamate decarboxylase Vision Disorders Nerve Tissue Proteins gamma-Aminobutyric acid 03 medical and health sciences Lactones Mice 0302 clinical medicine In vivo medicine Animals Beta (finance) gamma-Aminobutyric Acid Visual Cortex Mice Knockout Chemistry Glutamate Decarboxylase General Neuroscience Glutamate receptor Geniculate Bodies Membrane Proteins Electroencephalography General Medicine Brain Waves Mice Inbred C57BL Electrophysiology Disease Models Animal 030104 developmental biology Visual cortex medicine.anatomical_structure Ginkgolides Gene Expression Regulation Original Article Neuroscience Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery Photic Stimulation medicine.drug |
| Zdroj: | Neuroscience bulletin. 34(3) |
| ISSN: | 1995-8218 |
| Popis: | The visual system plays an important role in our daily life. In this study, we found that loss of dendritic cell factor 1 (DCF1) in the primary visual cortex (V1) caused a sight deficit in mice and induced an abnormal increase in glutamic acid decarboxylase 67, an enzyme that catalyzes the decarboxylation of glutamate to gamma aminobutyric acid and CO(2), particularly in layer 5. In vivo electrophysiological recordings confirmed a decrease in delta, theta, and beta oscillation power in DCF1-knockout mice. This study presents a previously unknown function of DCF1 in V1, suggests an unknown contact between DCF1 and GABA systems, and provides insight into the mechanism and treatment of visual deficits. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12264-018-0211-0) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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