Protracted pneumonitis in young infants associated with perinatally acquired cytomegaloviral infection
| Autor: | Sergio Stagno, Richard J. Whitley, Ralph E. Tiller, Charles A. Alford, David W. Reynolds, Dana M. Brasfield |
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| Rok vydání: | 1976 |
| Předmět: |
T-Lymphocytes
medicine.medical_treatment Pneumonia Viral Congenital cytomegalovirus infection Lung biopsy Infant Newborn Diseases Serology Uterine Cervical Diseases Pregnancy medicine Humans Sex organ Pneumonitis B-Lymphocytes business.industry Infant Newborn Infant Immunosuppression medicine.disease Immunoglobulin A Fetal Diseases Pneumonia Immunoglobulin M Immunoglobulin G Cytomegalovirus Infections Pediatrics Perinatology and Child Health Immunology Etiology Female business |
| Zdroj: | The Journal of Pediatrics. 89:16-22 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(76)80919-5 |
| Popis: | Two infants developed a protracted pneumonitis with lower respiratory obstruction beginning at one month of age. Lung biopsy in one suggested a viral etiology which prompted an extensive investigation of each infant for specific etiology. Virologic, serologic, immunologic, and electronmicroscopic studies indicated that cytomegalovirus was a major causative factor. The infections were apparently acquired at birth from infected maternal genital tracts and have persisted for prolonged periods of time. Evidence for gross immunologic defect as a precipitating cause was lacking. These infants serve to emphasize the possible pathologic potential of CMV when acquired in early life even in the absence of iatrogenic immunosuppression. |
| Databáze: | OpenAIRE |
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