Preparation and Characterization of Biodegradable Electrospun Polyanhydride Nano/Microfibers
| Autor: | Aijun Zhao, Qiuxiang Su, Shaobing Zhou, Hongsen Peng |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
business.product_category
Materials science Sebacic acid Polyesters Nanofibers Biomedical Engineering Bioengineering Ubbelohde viscometer chemistry.chemical_compound Differential scanning calorimetry Drug Stability X-Ray Diffraction Polyanhydrides Spectroscopy Fourier Transform Infrared Microfiber Nano Electrochemistry Copolymer Nanotechnology General Materials Science Fourier transform infrared spectroscopy Nuclear Magnetic Resonance Biomolecular General Chemistry Hydrogen-Ion Concentration Condensed Matter Physics Electrospinning Molecular Weight Chemical engineering chemistry Microscopy Electron Scanning business Decanoic Acids |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 10:6369-6375 |
| ISSN: | 1533-4880 |
| DOI: | 10.1166/jnn.2010.2535 |
| Popis: | The biodegradable polyanhydride copolymers P(CPP-SA) composed of p-carboxyhenoxy propane (CPP) and sebacic acid (SA) at weight ratios of 20:80, 35:65 and 50:50 were polymerized by a melt polycondensation process without catalyst. The copolymers were characterized by fourier transform infrared spectroscopy (FT-IR), 1H-nuclear magnetic resonance (1H-NMR), Ubbelohde viscometer, differential scanning calorimetry (DSC) and wide angle X-ray powder-diffraction (XRD). P(CPP-SA) nano/microfibers were the first time to be fabricated by electrospinning. The copolymers hold an excellent fibre-forming performance and the diameter range of 80-3,200 nm can be obtained. The in vitro degradation of the polyanhydride copolymers was evaluated in form of the nano/microfibers by investigating the change of fibrous morphology, weight loss and pH change of degradation medium. The experimental results showed that degradation rate was fast in the fist day and slow in the following period, furthermore the degradation rate decreased with the increase of the content of CPP in copolymers. Therefore, the electrospun polyanhydride nano/microfibers exhibited strong potential as drug delivery vehicle and tissue engineering scaffold. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|