Dual therapy versus triple therapy forHelicobacter pylori-associated duodenal ulcers
| Autor: | S.C.Sydney Chung, Augustine F. B. Cheng, James Y.W. Lau, Vincent K S Leung, Thomas K. W. Ling, Arthur K.C. Li, Joseph J.Y. Sung, R. Suen |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Randomization Adolescent Physiology medicine.medical_treatment Penicillins Gastroenterology Helicobacter Infections Pharmacotherapy Metronidazole Internal medicine Organometallic Compounds Humans Medicine Single-Blind Method Prospective Studies Omeprazole Aged Chemotherapy Chi-Square Distribution Helicobacter pylori biology business.industry Stomach Amoxicillin Middle Aged Tetracycline Anti-Ulcer Agents biology.organism_classification Anti-Bacterial Agents medicine.anatomical_structure Duodenal Ulcer Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Digestive Diseases and Sciences. 41:453-457 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/bf02282317 |
| Popis: | We compared the ulcer healing effect and eradication ofH. pylori by one-week triple therapy of bismuth, metronidazole, and tetracycline with two-week dual therapy of amoxicillin and omeprazole. One hundred twelve patients with confirmedH. pylori infection and duodenal ulcers were recruited in a prospective, randomized, single-blinded trial. Ulcer healing, eradication ofH. pylori in the stomach six weeks after randomization, and side effects reported by patients during the therapy. Duodenal ulcers were healed in 44 of 49 (89.8%, 95% CI 81.3–98.3%) patients receiving triple therapy and in 44 of 53 (83.0%, 95% CI 72.9–93.1%) patients receiving dual therapy (P=0.32).H. pylori was successfully eradicated in 41 of 49 (83.6%, 95% CI 73.4–94%) patients and in 40 of 53 (75.5%, 95% CI 63.9–87.1%) patients in the triple therapy group and the dual therapy group respectively (P=0.31). Side effects experienced by patients who received triple therapy were significantly more frequent than those who received dual therapy (P=0.0076). In conclusion, a two-week course of omeprazole and amoxicillin achieves a comparable rate ofH. pylori eradication and ulcer healing with fewer side effects. |
| Databáze: | OpenAIRE |
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