Demethoxycurcumin Inhibits In Vivo Growth of Xenograft Tumors of Human Cervical Cancer Cells
| Autor: | Jung-Yu Kuo, Yu Cheng Chou, Wen-Wen Huang, Shu-Fen Peng, Fu-Shin Chueh, Jin-Cherng Lien, Hung-Yi Chen, Jye-Yu Huang, Shou-Yi Sheng, Yi-Ping Huang, Hao-Yun Tung, Wan-Ni Huang |
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| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Curcumin Cell Mice Nude Uterine Cervical Neoplasms Apoptosis General Biochemistry Genetics and Molecular Biology HeLa Mice chemistry.chemical_compound Diarylheptanoids In vivo Cell Line Tumor Cervical carcinoma medicine Animals Humans Tumor xenograft Pharmacology biology Chemistry biology.organism_classification Xenograft Model Antitumor Assays In vitro medicine.anatomical_structure Cancer research Heterografts Female Human cancer Research Article HeLa Cells |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 0258-851X |
| Popis: | Background/aim Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. Therefore we investigated the antitumor effects of DMC on a HeLa cell xenograft model in nude mice in this study. Materials and methods Twenty-four nude mice were subcutaneously injected with HeLa cells. All mice were randomly divided into control, low-dose DMC (30 mg/kg), and high-dose DMC (50 mg/kg) groups and individual mice were treated intraperitoneally accordingly every 2 days. Results DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. Conclusion These effects and findings might provide evidence for investigating the potential use of DMC as an anti-cervical cancer drug in the future. |
| Databáze: | OpenAIRE |
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