Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results
| Autor: | Melissa Lamar, Linda C. Gallo, Albert Chai, Alberto R. Ramos, Martha L. Daviglus, Robert C. Kaplan, Marston E. Youngblood, Richard B. Lipton, Priscilla M. Vásquez, Neil Schneiderman, Myriam Fornage, Charles DeCarli, Donglin Zeng, Sonia Thomas, Hector M. González, Wassim Tarraf |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Gerontology Aging medicine.medical_specialty Epidemiology Apolipoprotein E4 Disease behavioral disciplines and activities Article 03 medical and health sciences Cellular and Molecular Neuroscience Sex Factors 0302 clinical medicine Developmental Neuroscience Risk Factors mental disorders Prevalence medicine Humans Dementia Cognitive Dysfunction Neuroepidemiology Prospective Studies 030212 general & internal medicine Cognitive decline Prospective cohort study Depression business.industry Health Policy Puerto Rico Neuropsychology Hispanic or Latino Middle Aged medicine.disease United States Psychiatry and Mental health Cardiovascular Diseases Female Neurology (clinical) Geriatrics and Gerontology business human activities Neurocognitive 030217 neurology & neurosurgery |
| Zdroj: | Alzheimers Dement |
| ISSN: | 1552-5260 |
| Popis: | Introduction We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos. Methods Middle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50–86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging–Alzheimer's Association diagnostic criteria. Results The overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI. Discussion MCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos. |
| Databáze: | OpenAIRE |
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