Osteoimmunology of tumor necrosis factor-alpha, IL-6, and RANTES/CCL5: a review of known and poorly understood inflammatory patterns in osteonecrosis
| Autor: | Johann Lechner, Volker von Baehr, Tatjana Rudi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemokine RANTES
0301 basic medicine Chemokine Osteolysis Osteoimmunology medicine.medical_treatment Osteoporosis Review CCL5 Bone resorption 03 medical and health sciences Medicine General Dentistry tumor necrosis factor-alpha biology business.industry maxillomandibular medicine.disease 030104 developmental biology Cytokine Immunology biology.protein Tumor necrosis factor alpha maxillomandibular osteoimmunology business bone resorption |
| Zdroj: | Clinical, Cosmetic and Investigational Dentistry |
| ISSN: | 1179-1357 |
| DOI: | 10.2147/ccide.s184498 |
| Popis: | Background The immune and bone systems are closely linked via cytokine cross-talk. This interdisciplinary field of research is referred to as osteoimmunology and pertains to inflammatory and osteoarticular diseases that feature the primary expression of tumor necrosis factor-alpha (TNF-α) and IL-6. Objective Are there bone resorptive processes wherein chronic inflammatory conditions are not linked to TNF-α and IL-6 expression, but rather to the expression of other cytokines? Materials and methods A comprehensive literature search was performed in PubMed Central. Discussion Although all diseases with cytokines involved in bone resorption (TNF-α and IL-6) are at the forefront of destructive inflammatory processes, there is one exception in the literature: fatty oxide osteoporosis/osteolysis in the jawbone (FDOJ), which is associated with significant bone softening. However, it should be noted that TNF-α and IL-6 fall below the levels found in a healthy jawbone in this condition. Another conspicuous finding is that there is a nearly 35-fold overexpression of the chemokine RANTES/CCL5 (R/C) in all FDOJ cases studied thus far in the literature. Conclusion FDOJ appears to represent a unique cytokine and inflammatory pattern from osteolysis in the body. R/C can be defined as the dominant carrier of a "maxillomandibular osteoimmunology". |
| Databáze: | OpenAIRE |
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