Structure–function associations in hippocampus in bipolar disorder
| Autor: | Hilary P. Blumberg, Jessica H. Kalmar, Marisa N. Spann, Fei Wang, E. Kale Edmiston, Linda Spencer, Lara G. Chepenik, Fay Y. Womer, Brian Pittman |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Hippocampus Neuropsychological Tests Audiology Verbal learning Article Memory medicine Humans Bipolar disorder Psychiatry Analysis of Variance Memory Disorders California Verbal Learning Test General Neuroscience Organ Size Middle Aged Verbal Learning medicine.disease Magnetic Resonance Imaging Neuropsychology and Physiological Psychology Free recall Antidepressant Female Analysis of variance Verbal memory Psychology |
| Zdroj: | Biological Psychology. 90:18-22 |
| ISSN: | 0301-0511 |
| DOI: | 10.1016/j.biopsycho.2012.01.008 |
| Popis: | Hippocampus volume decreases and verbal memory deficits have been reported in bipolar disorder (BD) as independent observations. We investigated potential associations between these deficits in subjects with BD. Hippocampus volumes were measured on magnetic resonance images of 31 subjects with BD and 32 healthy comparison (HC) subjects. The California Verbal Learning Test-Second Edition (CVLT) assessed verbal memory function in these subjects. Compared to the HC group, the BD group showed both significantly smaller hippocampus volumes and impaired performance on CVLT tests of immediate, short delay and long delay cued and free recall. Further, smaller hippocampus volume correlated with impaired performance in BD. Post-hoc analyses revealed a trend towards improved memory in BD subjects taking antidepressant medications. These results support associations between morphological changes in hippocampus structure in BD and verbal memory impairment. They provide preliminary evidence pharmacotherapy may reverse hippocampus-related memory deficits. |
| Databáze: | OpenAIRE |
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