The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway
| Autor: | Francesca Tarantini, Claudia Di Serio, Giulio Masotti, Silvia Pellerito, Igor Prudovsky, Niccolò Marchionni, Isabella Micucci, Matteo Landriscina, Laura Doria, Daniela Massi |
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| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
Biology Fibroblast growth factor Culture Media Serum-Free chemistry.chemical_compound Phosphatidylinositol 3-Kinases Cell Line Tumor medicine Humans Phosphatidylinositol Autocrine signalling Protein kinase B Melanoma PI3K/AKT/mTOR pathway Ions Molybdenum Akt/PKB signaling pathway medicine.disease Cell biology Gene Expression Regulation Neoplastic Oncology chemistry Tumor progression Cancer research Fibroblast Growth Factor 1 Proto-Oncogene Proteins c-akt Copper Signal Transduction |
| Zdroj: | Cancer letters. 267(1) |
| ISSN: | 0304-3835 |
| Popis: | Melanoma is a highly invasive tumor with elevated mortality rates. Progression and aggressiveness appear related to the achievement of an angiogenic phenotype. Melanoma cells express several angiogenic factors, including fibroblast growth factor (FGF)-1 and FGF-2. The autocrine production and release of FGFs and the subsequent activation of FGF receptors, have a central role in melanoma tumor progression. We demonstrated that FGF-1 is secreted from a human melanoma cell line, A375, under conditions of serum deprivation. The release of FGF-1 is inhibited by the copper chelator ammonium tetrathiomolybdate, suggesting a role of copper in the secretory pathway, and is triggered by activation of phosphatidylinositol 3-kinase (PI3K)/Akt intracellular signaling. Interestingly, overexpression or activation of Akt has been correlated with poor prognosis in melanoma patients. Our data indicate a novel role for Akt in supporting the progression of human melanomas and advocate the need for new treatments targeting PI3K/Akt signaling pathway, to control tumor development and progression. |
| Databáze: | OpenAIRE |
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