Influence of HIV Antigens on Functional Activity of Neutrophilic Granulocytes in

Autor:	A. T. Kozhich, Z. K. Suvorova, S. A. Moshnikov, D. I. Gabrilovich, Chikin Ld, V. V. Pokrovsky, Vadim S. Ivanov, O. V. Kolezonkova
Rok vydání:	1991
Předmět:	Adult Male chemistry.chemical_classification Lysis HIV Antigens Neutrophils Nitroblue Tetrazolium Neutrophile Immunology HIV Infections Peptide General Medicine Biology Granulocyte Gp41 Molecular biology medicine.anatomical_structure chemistry Antigen T-Lymphocyte Subsets medicine Humans Female CD8
Zdroj:	Scandinavian Journal of Immunology. 33:549-552
ISSN:	1365-3083 0300-9475
DOI:	10.1111/j.1365-3083.1991.tb02525.x
Popis:	The effect of nine HIV antigens, including eight synthetic peptides, on the functional activity of granulocytes was studied using the reduction of nitroblue tetrazolium test (NBT test). Some peptides partly suppressed the functional activity of granulocytes. The most pronounced suppression was caused by ImVL (HIV-1 lysate immobilized on plates for ELISA) and SP-7 (a synthetic peptide from the gp41 protein of HIV-1). The degrees to which the functional activity of granulocytes was suppressed by ImVL and SP-7 was in inverse proportion to the specific antibody concentrations. No correlation was found between the reduction in the NBT test value and the amount of CD4+, CD8+ cells on CD4/8 ratio.
Databáze:	OpenAIRE
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