Open pelvic fractures: Experience with recombinant factor VIIa, degloving and bowel injury
| Autor: | Gijsbert M. Overdevest, Martin J. Heetveld |
|---|---|
| Přispěvatelé: | Internal Medicine, Surgery |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Hemorrhage Factor VIIa Hemostatics Fractures Open medicine Humans Pelvic Bones Survival rate General Environmental Science Skin Degloving biology medicine.diagnostic_test business.industry Multiple Trauma Interventional radiology medicine.disease Combined Modality Therapy Embolization Therapeutic Recombinant Proteins Surgery Intestines Radiography Treatment Outcome Recombinant factor VIIa Damage control surgery Haemodynamic instability Acute Disease biology.protein Pelvic fracture General Earth and Planetary Sciences Injury Severity Score Female business |
| Zdroj: | Injury-International Journal of the Care of the Injured, 38(3), 384-391. Elsevier Ltd. |
| ISSN: | 0020-1383 |
| DOI: | 10.1016/j.injury.2006.09.026 |
| Popis: | Haemodynamic instability and additional injuries associated with open pelvic fractures lead to mortality risks of 45—60%. Several factors correlating with survival rate can be identified: age, injury severity score (ISS), associated injuries, pelvic boneligamentous instability, sizeandcontaminationof the wound, amount of blood transfused and the presence of bowel injury. Evolving multidisciplinary and mass transfusion protocols in the management of pelvic fractures have been shown to improve outcome in these challenging conditions. The foremost problem is haemorrhage control. In addition to damage control surgery and interventional radiology, the administration of recombinant activated factor VII (rFVIIa; Novoseven, Novo Nordisk, Denmark) in haemorrhage control could be beneficial. In this report, our procedures in three cases of open pelvic fracture caused by a rollover mechanism are described. The report is focused on haemorrhage control using rFVIIa from abdominal, retroperitoneal |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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