1 Alpha-hydroxyvitamin D3 suppresses colonic tumorigenesis induced by repetitive intrarectal injection of N-methyl-N-nitrosourea in rats
| Autor: | Kawaura A, Yukio Sawada, Takashi Shimoyama, M. Oda, Takahashi A, Noritoshi Tanida, S. Maekawa, Koji Sawada |
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| Rok vydání: | 1990 |
| Předmět: |
Vitamin
Adenoma Cancer Research medicine.medical_specialty Microgram Alpha (ethology) medicine.disease_cause chemistry.chemical_compound Administration Rectal Internal medicine Carcinoma medicine Animals Medium-chain triglyceride Carcinogen Chemistry Hydroxycholecalciferols Incidence Body Weight Methylnitrosourea medicine.disease Rats Inbred F344 Rats Endocrinology Oncology Concomitant Colonic Neoplasms Female Carcinogenesis |
| Zdroj: | Cancer letters. 55(2) |
| ISSN: | 0304-3835 |
| Popis: | The effect of 1 alpha-hydroxyvitamin D3 (1 alpha (OH)D3) on colonic tumorigenesis induced by chronic treatment with N-methyl-N-nitrosourea (MNU) was studied in rats. Seventy-four female F344 rats received an intrarectal injection of 1 mg of MNU once a week for 40 weeks. Two-thirds of rats were given concomitant administration of 0.2 ml of medium chain triglyceride (MCT) or MCT containing 0.04 microgram of 1 alpha (OH)D3 through an intragastric route thrice weekly. Numbers of rats bearing colonic tumor were 21 in MNU alone (n = 24), 17 in MNU + MCT (n = 25) and 12 in MNU + 1 alpha (OH)D3 group (n = 25) (uncorrected chi 2 = 8.72). The result indicated that colonic tumorigenesis induced by the chronic treatment with MNU was suppressed by oral supplementation of 1 alpha (OH)D3 and the inhibitory effect of 1 alpha (OH)D3 was partly due to the effect of MCT. |
| Databáze: | OpenAIRE |
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