The cumulative incidence of and risk factors for morphometric severe vertebral fractures in Japanese men and women: the ROAD study third and fourth surveys
| Autor: | Hiroshi Hashizume, Shu Tanaka, Kozo Nakamura, Munehito Yoshida, Toru Akune, Yoshiki Asai, Toshiko Iidaka, Hiroshi Yamada, Syunji Tsutsui, Hiroyuki Oka, Noriko Yoshimura, Yasushi Oshima, Shigeyuki Muraki, Hiroshi Kawaguchi, Chiaki Horii |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis Population Logistic regression Cohort Studies Japan Bone Density Risk Factors Internal medicine Osteoarthritis Prevalence Medicine Humans Cumulative incidence Risk factor education Aged education.field_of_study business.industry Incidence (epidemiology) Incidence Odds ratio Middle Aged medicine.disease Spinal Fractures Female business Cohort study |
| Zdroj: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 33(4) |
| ISSN: | 1433-2965 |
| Popis: | This population-based cohort study with a 3-year follow-up revealed that the annual incidence rates of vertebral fracture (VF) and severe VF (sVF) were 5.9%/year and 1.7%/year, respectively. The presence of mild VF at the baseline was a significant risk factor for incident sVF in participants without prevalent sVF. This study aimed to estimate the incidence of morphometric vertebral fracture (VF) and severe VF (sVF) in men and women and clarify whether the presence of a mild VF (mVF) increases the risk of incident sVF. Data from the population-based cohort study, entitled the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study, were analyzed. In total, 1190 participants aged ≥ 40 years (mean age, 65.0 ± 11.2) years completed whole-spine lateral radiography both at the third (2012–2013, baseline) and fourth surveys performed 3 years later (2015–2016, follow-up). VF was defined using Genant’s semi-quantitative (SQ) method: VF as SQ ≥ 1, mVF as SQ = 1, and sVF as SQ ≥ 2. Cumulative incidence of VF and sVF was estimated. Multivariate logistic regression analyses were performed to evaluate risk factors for incident sVF. The baseline prevalence of mVF and sVF were 16.8% and 6.0%, respectively. The annual incidence rates of VF and sVF were 5.9%/year and 1.7%/year, respectively. The annual incidence rates of sVF in participants without prevalent VF, with prevalent mVF, and with prevalent sVF were 0.6%/year, 3.8%/year, and 11.7%/year (p |
| Databáze: | OpenAIRE |
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