Polymorphisms in immune-mediator genes and the risk of dengue virus infection: Lights from a systematic revaluation by Bayesian approaches

Autor: Alessandro Luiz Araújo Bentes Leal, Fyama Araújo da Silva, Jae Il Shin, Gwang Hun Jeong, Gustavo Portela Ferreira, Daniel Fernando Pereira Vasconcelos, José Rogério Souza Monteiro, Aline Andrade de Sousa, Felipe Rodolfo Pereira da Silva, Anna Carolina Toledo da Cunha Pereira
Rok vydání: 2022
Předmět:
Zdroj: Cytokine. 157:155955
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2022.155955
Popis: Dengue fever is a clinical manifestation of dengue virus (DENV) infection well defined by the intense host immune response with the development of high fever, anorexia, headache and muscle pain. Several immune mediators are involved in the pathophysiology of DENV infection, in which polymorphisms in immune molecule genes contribute with the susceptibility and severity of the infection. Several meta-analyses are available with significant findings in the association between genetic variants in immune-mediator genes and dengue, though the results may be false positive. Hence, to solve this issue, we have performed a systematic revaluation with Bayesian approaches to verify the false positive rate in these results. A systematic search was performed for meta-analytic studies on the aforementioned issue. The calculations of false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP) at the prior probability of 10
Databáze: OpenAIRE
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