Prognostic value of pre-surgical plasma PAI-1 (plasminogen activator inhibitor-1) levels in breast cancer
| Autor: | Raffaele Palmirotta, Mario Roselli, V. Sini, Annalisa Savonarola, Girolamo Del Monte, Patrizia Ferroni, Filippo Ciatti, Anastasia Laudisi, Francesca Martini, Fiorella Guadagni |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Prognostic variable Settore MED/06 - Oncologia Medica Single-nucleotide polymorphism Breast Neoplasms Promoter Regions chemistry.chemical_compound Breast cancer Polymorphism Genetic Humans Prognosis Aged Recurrence Alleles Promoter Regions Genetic Survival Rate Aged 80 and over Plasminogen Activator Inhibitor 1 Follow-Up Studies Middle Aged Female Genetic Internal medicine medicine Genetic predisposition 80 and over Polymorphism business.industry Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio Cancer Hematology medicine.disease Endocrinology chemistry Plasminogen activator inhibitor-1 Breast disease business Plasminogen activator |
| Popis: | Plasminogen activator inhibitor (PAI-1) may have an independent prognostic value in breast cancer (BC). PAI-1 4G/5G polymorphism may have significance for antigen expression. Thus, we analyzed the possible associations between PAI-1 4G/5G polymorphism, plasma PAI-1 levels, and clinicopathological features of breast cancer (BC) patients.PAI-1 4G/5G polymorphism (both on germinal and tumor DNA) and plasma PAI-1 levels were investigated in 99 BC patients and 50 unrelated healthy women similar for age and menopausal status.No association was found between allele frequencies and clinicopathological features of BC or plasma antigen levels. Plasma PAI-1 levels were higher in BC compared to controls (p=0.002), particularly in patients with large tumors (p0.001). 5-year follow-up was achieved in 79 patients: 30% had relapsing disease, 63% with positive compared to 37% with negative PAI-1 levels (p0.05). 5-year relapse-free survival rate of positive PAI-1 was 46% vs., 77% of negative patients (p=0.02).We may conclude that plasma PAI-1 levels in BC patients could represent a useful prognostic variable for relapse, although PAI-1 polymorphism might not represent a genetic susceptibility factor. |
| Databáze: | OpenAIRE |
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