A primary extranodal lymphoma associated with IgM-κ paraproteinaemia: Different secretory capacities of cutaneous and circulating lymphoma cells
| Autor: | Shuichi Katagiri, Yoshio Kanayama, Tadahiro Tsubakio, Seiichiro Tarui, Toshiharu Tamaki, M. Ohnishi, J. Kuyama, K. Saeki, Yonezawa T |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Lymphoma Mucocutaneous zone Paraproteinemias Immunoglobulin kappa-Chains medicine Humans Lymphocytes Extranodal Involvement B cell Skin business.industry Hematology Middle Aged medicine.disease Non-Hodgkin's lymphoma Microscopy Electron medicine.anatomical_structure Immunoglobulin M Subcutaneous nodule Monoclonal Immunology Female business Subcutaneous tissue |
| Zdroj: | Scandinavian Journal of Haematology. 36:217-220 |
| ISSN: | 0036-553X |
| Popis: | We report a patient with non-Hodgkin's lymphoma of small lymphocytic type with IgM-kappa monoclonal gammopathy who developed extranodal involvement with orbital and nasal manifestations, followed by generalized subcutaneous nodules. Immunological study disclosed that the peripheral blood and the subcutaneous nodule were both involved in a common monoclonal proliferation of B cells at various stages of differentiation, including secretory cells which accounted for the serum paraprotein. The secretory capacity was far greater in the peripheral blood than in the subcutaneous tissue. These clinical and immunological manifestations might reflect the physiological behaviour of a particular B cell subset which shows a preference for mucocutaneous sites to secrete IgM in the peripheral blood. |
| Databáze: | OpenAIRE |
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