Association between Obstructive Sleep Apnea and Myocardial Infarction: A Systematic Review

Autor: Cristina Salles, Fernanda Porto, Yuri Saho Sakamoto
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
Sleep Wake Disorders
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Polissonografia / métodos
Polysomnography / methods
Polysomnography
Myocardial Infarction
Review Article
Review
030204 cardiovascular system & hematology
03 medical and health sciences
Sex Factors
0302 clinical medicine
Risk Factors
Internal medicine
Humans
Medicine
Adults
Infarto do Miocárdio
Adultos
030212 general & internal medicine
Myocardial infarction
Transtornos do Sono-Vigilia
Stroke
Aged
Sleep Apnea
Obstructive
medicine.diagnostic_test
business.industry
Sleep apnea
Apnea
Revisão
Middle Aged
medicine.disease
respiratory tract diseases
Obstructive sleep apnea
Apneia do Sono Tipo Obstrutiva
lcsh:RC666-701
Hypertension
Physical therapy
Female
Electronic data
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Hypopnea
Zdroj: Arquivos Brasileiros de Cardiologia v.108 n.4 2017
Arquivos Brasileiros de Cardiologia
Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
Arquivos Brasileiros de Cardiologia, Iss 0
Arquivos Brasileiros de Cardiologia, Volume: 108, Issue: 4, Pages: 361-369, Published: 30 MAR 2017
Popis: Obstructive sleep apnea (OSA) has been associated to cardiovascular risk factors. However, the association between OSA and cardiovascular disease is still controversial. The objective of the present study was to verify the association between OSA and myocardial infarction (MI). This is a systematic review of the literature performed through electronic data sources MEDLINE/PubMed, PubMed Central, Web of Science and BVS -Biblioteca Virtual em Saúde (Virtual Health Library). The descriptors used were: 'obstructive sleep apnea' AND 'polysomnography' AND 'myocardial infarction' AND 'adults NOT 'treatment.' The present work analysed three prospective studies, selected from 142 articles. The studies followed a total sample of 5,067 OSA patients, mostly composed by male participants. All patients underwent night polysomnography, and all studies found an association between OSA and fatal and non-fatal cardiovascular outcomes. Thus, we were able to observe that 644 (12.7%) of the 5,067 patients suffered MI or stroke, or required a revascularization procedure, and 25.6% of these cardiovascular events were fatal. MI was responsible for 29.5% of all 644 analysed outcomes. There is an association between OSA and MI, in male patients, and apnea and hypopnea index (AHI) are the most reliable markers. Resumo A apneia obstrutiva do sono (AOS) tem sido associada a fatores de risco cardiovascular, porém a relação entre a AOS e doença cardiovascular ainda é controversa. O objetivo do presente estudo foi verificar a associação entre AOS e infarto do miocárdio (IM). Revisão sistemática de literatura por meio das fontes de dados eletrônicas MEDLINE/PubMed, PubMed Central, Web of Science e Biblioteca Virtual em Saúde (BVS). Os descritores utilizados foram: "obstructive sleep apnea" AND "polysomnography" AND "myocardial infarction" AND "adults" NOT "treatment".O presente trabalho analisou três estudos prospectivos, selecionados dentre 142 artigos encontrados. Os estudos acompanharam uma amostra total de 5.067 pacientes diagnosticados com AOS, composta majoritariamente por participantes do sexo masculino. Todos os pacientes realizaram polissonografia noturna, e todas as pesquisas encontraram associação entre AOS e desfechos cardiovasculares fatais e não fatais. Assim, foi possível observar que 644 (12,7%) dos 5.067 pacientes sofreram IM ou acidente vascular cerebral, ou precisaram de procedimento de revascularização, sendo que 25,6% desses eventos cardiovasculares foram fatais. O IM foi responsável por 29,5% do total de 644 desfechos analisados. Existe associação entre AOS e IM, no sexo masculino, sendo o índice de apneia e hipopneia (IAH) um dos marcadores mais fidedignos.
Databáze: OpenAIRE
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