Intra-articular Duration of Durolane™ after Single Injection into the Rabbit Knee
| Autor: | Roland Hjelm, Åsa Wiebensjö, Katarina Edsman, Helena Lärkner, A. Urban Höglund, Anne Helander Kenne, Jacques Näsström, Lars I. Nord, Anders Karlsson |
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| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Durolane™ Biomedical Engineering intra-articular Physical Therapy Sports Therapy and Rehabilitation Osteoarthritis chemistry.chemical_compound Intra articular hyaluronic acid Hyaluronic acid Immunology and Allergy Medicine business.industry duration Histology Rabbit (nuclear engineering) Original Articles Single injection medicine.disease Exponential models Surgery osteoarthritis chemistry Rabbit model business Nuclear medicine |
| Zdroj: | Cartilage |
| ISSN: | 1947-6043 1947-6035 |
| DOI: | 10.1177/1947603511400184 |
| Popis: | Objective: The aim of the present study was to investigate the intra-articular duration of Durolane™ in a rabbit model to allow comparison between Durolane™ residence time and data reported for other hyaluronic acid products as well as native hyaluronic acid. Design: 14C-labeled Durolane™ was manufactured by labeling the cross-linker used for stabilization. A single injection of approximately 0.3 mL 14C-labeled Durolane™ was administered intra-articularly in both knee joints of male New Zealand White rabbits. At days 1, 2, 3, 7, 28, 60, 96, and 120 after injection, the knee joints of 4 animals were collected, and the radioactivity of the remaining gel was measured. The obtained data were fitted by exponential models to calculate the half-life of the gel. Two additional rabbits were used for histology of the joint 127 days after the injection. Results: The elimination of 14C-labeled Durolane™ followed first-order kinetics with an apparent half-life of approximately 32 days. Histology showed no morphological changes in the knee joints. Conclusions: This study shows that Durolane™ has a half-life of 32 days in the rabbit knee joint, which is much longer compared to literature data on hyaluronic acid and other modified hyaluronic acid products. |
| Databáze: | OpenAIRE |
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