A New Cytotoxic Daphnane Diterpenoid, Rediocide G, from Trigonostemon reidioides
| Autor: | Chitkavee Pavaro, Pongpun Siripong, Somsak Ruchirawat, Wongsatit Chuakul, Nopporn Thasana, Atchara Tempeam |
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| Rok vydání: | 2005 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Molecular Conformation Plant Roots KB Cells Terpene chemistry.chemical_compound Cell Line Tumor Trigonostemon Scopoletin Drug Discovery Humans Cytotoxic T cell Cell Proliferation Carbon Isotopes Stigmasterol Natural product biology Euphorbiaceae Stereoisomerism General Chemistry General Medicine Reference Standards biology.organism_classification Terpenoid chemistry Macrolides Diterpenes Drug Screening Assays Antitumor Protons Two-dimensional nuclear magnetic resonance spectroscopy HeLa Cells |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 53:1321-1323 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.53.1321 |
| Popis: | Rediocide G (7), a new daphnane diterpenoid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae), together with two congeners, rediocide A and rediocide B, (+)-syringaresinol, scopoletin, tomentin and stigmasterol. The structure of the new natural product was elucidated by comparison of its NMR and mass spectral data with those of previously known rediocides and confirmed by extensive 2D NMR spectral analysis. Rediocide G (7) was found to be cytotoxic to various cancer cell lines. |
| Databáze: | OpenAIRE |
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