Preliminary evaluation of the DDS-PC inventory: a new tool to assess impulsive-compulsive behaviours associated to dopamine replacement therapy in Parkinson's disease
| Autor: | Mario Baratti, Giulio Cabri, Maurizio Avanzi, Elena Uber, Flavio Bonfà, Silvia Cabrini |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Personality Tests medicine.medical_specialty Parkinson's disease Psychometrics Compulsive Personality Disorder Dopamine Dopamine Agents Dermatology Neuropsychological Tests Impulsivity Antiparkinson Agents Levodopa Reward Punding Psychoticism Surveys and Questionnaires medicine Humans Longitudinal Studies Psychiatry Dopamine dysregulation syndrome Aged Binge eating Parkinson Disease General Medicine Middle Aged medicine.disease Disruptive Impulse Control and Conduct Disorders Psychiatry and Mental health Caregivers ROC Curve Gambling Hypersexuality Female Neurology (clinical) medicine.symptom Psychology Psychopathology |
| Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 30(4) |
| ISSN: | 1590-3478 |
| Popis: | Dopaminergic medications could increase the occurrence of a set of dysregulated behaviours in Parkinson’s disease (PD), including reward-seeking behaviours (pathological gambling, hypersexuality, compulsive shopping, binge eating, reckless driving), punding and compulsive medication use. We report a preliminary evaluation of a questionnaire to assess the presence of these impulsive–compulsive behaviours associated to dopamine replacement therapy in PD. We screened 38 patients and their caregivers, comparing dopamine dysregulation syndrome (DDS) patients and non-DDS patients. The questionnaire was well accepted and demonstrated a preliminary good discriminant validity (p = 0.000). In addition, clinically relevant dysregulated condition is associated with a younger age (p = 0.006), younger age at disease onset (p = 0.001), levodopa-equivalent daily dose (p = 0.029), UPDRS III (p = 0.021), increased global psychopathology (interpersonal sensitivity and psychoticism), and differences in our inventory (p = 0.000). These preliminary results suggest that the DDS-PC inventory could help to identify patients experiencing impulsive–compulsive behaviours associated to DDS. |
| Databáze: | OpenAIRE |
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