Elevated Heterozygosity in Adults Relative to Juveniles Provides Evidence of Viability Selection on Eagles and Falcons
| Autor: | Kolbe Leonard, Nadia B. Fernandez, J. Andrew DeWoody, Jacqueline M. Doyle, Peter H. Bloom, Janna R. Willoughby, Todd E. Katzner, Douglas A. Bell, Evgeny A. Bragin |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine Eagle Heterozygote Eagles Quantitative Trait Loci Zoology Biology Balancing selection 010603 evolutionary biology 01 natural sciences Loss of heterozygosity 03 medical and health sciences Effective population size Gene Frequency biology.animal Genetics Juvenile Animals Genetic variability Selection Genetic Molecular Biology Genetics (clinical) Selection (genetic algorithm) Alleles Whole Genome Sequencing Age Factors Computational Biology Genetic Variation Molecular Sequence Annotation Genetic load 030104 developmental biology Biotechnology |
| Zdroj: | The Journal of heredity. 110(6) |
| ISSN: | 1465-7333 |
| Popis: | Viability selection yields adult populations that are more genetically variable than those of juveniles, producing a positive correlation between heterozygosity and survival. Viability selection could be the result of decreased heterozygosity across many loci in inbred individuals and a subsequent decrease in survivorship resulting from the expression of the deleterious alleles. Alternatively, locus-specific differences in genetic variability between adults and juveniles may be driven by forms of balancing selection, including heterozygote advantage, frequency-dependent selection, or selection across temporal and spatial scales. We use a pooled-sequencing approach to compare genome-wide and locus-specific genetic variability between 74 golden eagle (Aquila chrysaetos), 62 imperial eagle (Aquila heliaca), and 69 prairie falcon (Falco mexicanus) juveniles and adults. Although genome-wide genetic variability is comparable between juvenile and adult golden eagles and prairie falcons, imperial eagle adults are significantly more heterozygous than juveniles. This evidence of viability selection may stem from a relatively smaller imperial eagle effective population size and potentially greater genetic load. We additionally identify ~2000 single-nucleotide polymorphisms across the 3 species with extreme differences in heterozygosity between juveniles and adults. Many of these markers are associated with genes implicated in immune function or olfaction. These loci represent potential targets for studies of how heterozygote advantage, frequency-dependent selection, and selection over spatial and temporal scales influence survivorship in avian species. Overall, our genome-wide data extend previous studies that used allozyme or microsatellite markers and indicate that viability selection may be a more common evolutionary phenomenon than often appreciated. |
| Databáze: | OpenAIRE |
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