Animal model of primary hyperparathyroidism
| Autor: | G. V. Segre, P. Jaeger, W. Jones, John P. Hayslett, T. L. Clemens, Michael Kashgarian, Roland Baron |
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| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Parathyroid hormone Kidney Bone and Bones Phosphorus metabolism Calcitriol Physiology (medical) Internal medicine medicine Animals Vitamin D Acid-Base Equilibrium Calcium metabolism Hyperparathyroidism Chemistry Phosphorus Rats Inbred Strains medicine.disease Peptide Fragments Rats Disease Models Animal Endocrinology Parathyroid Hormone Thyroidectomy Calcium Renal threshold Nephrocalcinosis Primary hyperparathyroidism Hypophosphatemia |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 252:E790-E798 |
| ISSN: | 1522-1555 0193-1849 |
| Popis: | An experimental model of hyperparathyroidism was developed in the rat to simulate primary hyperparathyroidism in humans. In this model thyroparathyroidectomized (TPTX) or parathyroidectomized (PTX) animals were infused for 6 days with an amount of bovine synthetic parathyroid hormone (PTH)-(1-34) fragment to restore plasma calcium levels to normal (0.7 U X h-1) or with PTH at twofold (1.4 U X h-1) or threefold (2.1 U X h-1) this basal level. Animals infused with 2.1 U X h-1 of bovine PTH-(1-34) exhibited hypercalcemia, hypophosphatemia, a reduction in theoretical renal threshold for phosphate and an increase in 1,25-dihydroxyvitamin D plasma levels that were approximately threefold the control value. In addition, these animals demonstrated nephrocalcinosis and changes of bone histology that were typical of the findings in patients with primary hyperparathyroidism. In contrast, in animals infused at 1.4 U X h-1, plasma calcium, phosphate, and theoretical renal threshold for phosphate remained within normal limits, but plasma 1,25-dihydroxyvitamin D was increased above control, suggesting that increased activity of 1 alpha-hydroxylase may be the most sensitive index of increased PTH levels. This animal model permits sustained elevation of PTH plasma levels at basal or pathologically elevated levels and should provide an effective means by which to evaluate the consequences of chronic hyperparathyroidism on epithelial function, bone, and other organ systems. |
| Databáze: | OpenAIRE |
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