Evaluation of the Angelchik Antireflux Prosthesis Using a Model for Esophageal Reflux in Rhesus Monkeys
| Autor: | Geoffrey M. Graeber, Carmel M. Cordova, Donald O. Castell, Abraham H. Dachman, Stanley B. Benjamin, Darryl H. Patrick, David J. Cohen, Arnold C. Friedman |
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| Rok vydání: | 1986 |
| Předmět: |
Pulmonary and Respiratory Medicine
Myotomy medicine.medical_specialty Manometry medicine.medical_treatment Nissen fundoplication Prosthesis Pressure otorhinolaryngologic diseases medicine Animals Antireflux prosthesis business.industry Stomach Reflux Prostheses and Implants Macaca mulatta digestive system diseases Surgery Disease Models Animal medicine.anatomical_structure Evaluation Studies as Topic Gastroesophageal Reflux Esophageal sphincter Cardiology and Cardiovascular Medicine business Esophageal reflux |
| Zdroj: | The Annals of Thoracic Surgery. 41:135-142 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/s0003-4975(10)62653-7 |
| Popis: | Minimal data are available about the Angelchik antireflux prosthesis although it has been inserted in more than 14,000 patients. The present animal study was designed to evaluate the effectiveness and mechanism of action of this prosthesis. A reproducible model of esophageal reflux in primates was created using a double myotomy. Lower esophageal sphincter (LES) pressure and reflux score were improved significantly in animals by insertion of an Angelchik antireflux prosthesis, a modified antireflux prosthesis, or a Nissen fundoplication. Manometrically determined LES length was increased after insertion of an Angelchik antireflux prosthesis but not by a Nissen fundoplication or sham operation. Complications after insertion of the modified prosthesis included intraluminal erosion, fibrous stricture, and slippage of the device over the stomach. |
| Databáze: | OpenAIRE |
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