Antibiotics acting as neuroprotectants via mechanisms independent of their anti-infective activities
| Autor: | Steve A. Carlson, Sri Harsha Kanuri, Gregory S.A. Mlynarczyk, Stephen J. Anderson, Sreemoyee Acharya, Garrett R. McCormack, Jennifer K. Lange, Matthew L. Stock, Naveen Kondru, Matthew T. Brewer, Kara J. Fiedler |
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| Rok vydání: | 2013 |
| Předmět: |
Sirolimus
Pharmacology medicine.drug_class Multiple sclerosis Antibiotics Excitotoxicity Minocycline Biology beta-Lactams medicine.disease_cause medicine.disease Neuroprotection Anti-Bacterial Agents Pathogenesis Cellular and Molecular Neuroscience Neuroprotective Agents medicine Animals Humans Nervous System Diseases Amyotrophic lateral sclerosis Protein kinase A medicine.drug |
| Zdroj: | Neuropharmacology. 73:174-182 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2013.04.059 |
| Popis: | This review considers available evidence that some antibiotics have ancillary neuroprotective effects. Notably, β-lactam antibiotics are believed to increase the expression of glutamate transporter GLT1, potentially relieving the neurological excitotoxicity that characterizes disorders like amyotrophic lateral sclerosis. Minocycline has shown promise in reducing the severity of a number of neurological diseases, including multiple sclerosis, most likely by reducing apoptosis and the expression of inflammatory mediators in the brain. Rapamycin inhibits the activity of a serine/threonine protein kinase that has a role in the pathogenesis of numerous neurologic diseases. Herein we examine the unique neuroprotective aspects of these drugs originally developed as anti-infective agents. |
| Databáze: | OpenAIRE |
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