Cardiovascular disease risk assessment in patients with familial Mediterranean fever related renal amyloidosis

Autor:	Bradley C. Jackson, Cengizhan Acikel, David Piskin, Erkan Demirkaya, Roberta A. Berard, Helen J. Lachmann, Micol Romano, Mahmut Ilker Yilmaz, Juan Jesus Carrero
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty Familial Mediterranean fever lcsh:Medicine 030204 cardiovascular system & hematology Risk Assessment Pediatrics Renal amyloidosis Article 03 medical and health sciences Young Adult 0302 clinical medicine AA amyloidosis Rheumatology Internal medicine Chronic kidney disease Medicine Humans Risk factor lcsh:Science 030203 arthritis & rheumatology Multidisciplinary Proteinuria business.industry Proportional hazards model Amyloidosis lcsh:R Middle Aged medicine.disease Familial Mediterranean Fever Fibroblast Growth Factor-23 Cardiovascular diseases Cardiovascular Diseases Female Kidney Diseases lcsh:Q medicine.symptom business Risk assessment
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Paediatrics Publications Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-020-75433-7
Popis:	Chronic inflammation and proteinuria is a risk factor for cardiovascular disease (CVD) in patients with chronic kidney diseases and rheumatologic disorders. Our aim was to investigate the CVD events (CVDEs) and survival between the patients with FMF-related AA amyloidosis and glomerulonephropathies (GN) to define possible predictors for CVDEs. A prospective follow-up study with FMF-amyloidosis and glomerulonephropathy (GN) was performed and patients were followed for CVDEs. Flow-mediated dilatation (FMD), FGF-23, serum lipid, hsCRP levels, BMI and HOMA were assessed. A Cox regression analysis was performed to evaluate the risk factors for CVDEs. There were 107 patients in the FMF-amyloidosis group and 126 patients with GN group. Forty-seven CVDEs were observed during the 4.2-years follow up; all 28 patients in the FMF-amyloidosis group and 14/19 patients with GN developed CVDEs before the age of 40 (p = 0.002). CVD mortality was 2.8 times higher (95% CI 1.02–7.76) in patients with FMF-amyloidosis. Across both groups, FMD and FGF23 (p
Databáze:	OpenAIRE
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