Longitudinal study of cerebral blood flow in Alzheimer's disease using single photon emission tomography
| Autor: | Deborah Anne Koder, Henry Brodaty, Rakesh Gaur, Susanne Meares, Walter Haindl, Alexandra J. Walker, Perminder S. Sachdev |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Neuroscience (miscellaneous) Perfusion scanning Neuropsychological Tests Lateralization of brain function Central nervous system disease Alzheimer Disease Internal medicine medicine Humans Dementia Radiology Nuclear Medicine and imaging Longitudinal Studies Cerebral perfusion pressure Aged Tomography Emission-Computed Single-Photon medicine.diagnostic_test Brain Neuropsychological test Middle Aged medicine.disease Surgery Psychiatry and Mental health Cerebral blood flow Regional Blood Flow Cardiology Female Alzheimer's disease Cognition Disorders Tomography X-Ray Computed Psychology |
| Zdroj: | Psychiatry Research: Neuroimaging. 68:133-141 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/s0925-4927(96)02792-8 |
| Popis: | Ten patients with probable Alzheimer's disease were assessed at baseline and a mean 2 years later using a battery of neuropsychological tests, CT scans and Tc99m-HMPAO SPECT scans. The subjects had declined significantly in their functional indices. Cerebral perfusion measures declined in the parietal lobes, left hemisphere and whole brain, but the overall decline did not reach statistical significance. The decline in brain perfusion did not correlate significantly with the decline in various indices of neuropsychological function, either globally or for specific brain regions. The index of cerebral perfusion correlated significantly with global indices of neuropsychological function at baseline but not at follow-up. No single perfusion index was a significant predictor of clinical progression of dementia. |
| Databáze: | OpenAIRE |
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