W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway
| Autor: | Guang Liang, Lingyi Shi, Guanqun Huang, Shilong Ying, Bixia Weng, Yanting Kang, Xiaojing Du, Zhankun Wang, Qiuxiang Chen, Jianzhang Wu, Rong Jin, Yiqun Xia |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Curcumin Cell cycle checkpoint Apoptosis Cyclopentanes IκB kinase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine NF-KappaB Inhibitor alpha Stomach Neoplasms Cell Line Tumor medicine Humans Neoplasm Invasiveness Phosphorylation Cell Proliferation Tumor Necrosis Factor-alpha Chemistry Cell growth NF-kappa B Transcription Factor RelA Cancer Cell Cycle Checkpoints General Medicine medicine.disease I-kappa B Kinase Cell biology Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Proteolysis Cancer cell I-kappa B Proteins Tumor necrosis factor alpha Signal Transduction |
| Zdroj: | Tumor Biology. 37:4791-4801 |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.1007/s13277-015-4277-2 |
| Popis: | The therapeutic agent selectively killing cancer cells is urgently needed for gastric cancer treatment. Curcumin has been investigated for its effect on the cancer treatment because of its significant therapeutic potential and safety profile. A synthetic unsymmetry mono-carbonyl compound termed W346 was developed from curcumin. In this study, we investigated the potential antineoplastic effect and mechanism of W346 against human gastric cancer cells. W346 suppressed the proliferation and invasion, blocked cell cycle arrest at G2/M phase, and increased apoptosis in gastric cancer cells, and it presented obviously improved anticancer activity than curcumin. Moreover, W346 effectively inhibited tumor necrosis factor (TNF-α)-induced NF-κB activation by suppressing IKK phosphorylation, inhibiting IκB-α degradation, and restraining the accumulation of NF-κB subunit p65 nuclear translocation. W346 also affected NF-κB-regulated downstream products involved in cycle arrest and apoptosis. In a word, W346 exhibited significantly improved anti-gastric cancer activity over curcumin by targeting NF-κB signaling pathway, and it is likely to be a promising starting point for the development of curcumin-based therapeutic agent. |
| Databáze: | OpenAIRE |
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