Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP
| Autor: | Steven C. King, C Brechtel, S R Fleming |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
GABA Plasma Membrane Transport Proteins
Organic anion transporter 1 Proline Nipecotic Acids Organic Anion Transporters medicine.disease_cause Microbiology Substrate Specificity Piperidines Membrane Transport Modulators medicine Escherichia coli Molecular Biology gamma-Aminobutyric Acid biology Permease Membrane transport protein Escherichia coli Proteins Nicotinic Acids Substrate (chemistry) Membrane Transport Proteins Biological Transport Biochemistry Genes Bacterial biology.protein Research Article |
| Zdroj: | Journal of bacteriology. 177(18) |
| ISSN: | 0021-9193 |
| Popis: | Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow. |
| Databáze: | OpenAIRE |
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