Prognostic Factors and Differences in Survival of Right and Left Colon Carcinoma: A STROBE Compliant Retrospective Cohort Study
| Autor: | Doris Carmona-Herrera, Roberto Herrera-Goepfert, Norma A. Meléndez-Ponce, José F. Carrillo, Dolores Gallardo-Rincón, Sagrario Gonzalez-Trejo, Francisco J. Ochoa-Carrillo, Leonora Beltran, Vincenzo Aiello-Crocifoglio, Luis F. Oñate-Ocaña |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Multivariate analysis Colorectal cancer Adenocarcinoma 03 medical and health sciences 0302 clinical medicine Left colon Internal medicine Outcome Assessment Health Care Carcinoma Medicine Humans Neoplasm Staging Proportional Hazards Models Retrospective Studies business.industry Proportional hazards model Cancer Retrospective cohort study General Medicine Middle Aged medicine.disease Prognosis Survival Analysis Clinical trial 030104 developmental biology 030220 oncology & carcinogenesis Colonic Neoplasms Female Lymph Nodes business |
| Zdroj: | Archives of medical research. 50(2) |
| ISSN: | 1873-5487 |
| Popis: | Right-colon cancer (RCC) presents differences with Left-colon cancer (LCC) in terms of Overall survival (OS), but certain reports provide conflicting findings. Our objective is to define differences regarding prognostic factors in RCC and LCC by multivariate analysis.Retrospective cohort including patients treated from 1992-2016. The Kaplan-Meier and Cox models were used to define prognostic factors.871 patients had RCC and 748 LCC; mean age was 58.1. Location was associated with socioeconomic status, body mass, blood hemoglobin, serum albumin, lymphocyte count and Prognostic nutritional index (PNI). Distribution of TNM stages was similar between groups, as well as gender, age, surgical morbidity/mortality; 72.3% of RCC and 83.2% of LCC were well/moderately differentiated (p 0.0001). Mean surgical lymph-node retrieval was 19.3 (SD14.6) for RCC and 15.7 (SD13.1) for LCC (p 0.0001). Median OS was 5.2 (95% CI 3.9-6.5) for RCC, and 3.2 years (95% CI 2.1-4.4) for LCC (p = 0.426). OS was different between RCC and LCC by stratified analyses within PNI, TNM, differentiation and R classification. RCC presents different OS in stages IIIC, and IVB than LCC.Differences between RCC and LCC were mainly by immunonutritional variables. Differences in OS were found after stratified analysis of PNI, TNM stages, differentiation degree, and R classification. Location of the neoplasm in the colon should be considered in the design of clinical trials in patients with colon cancer. |
| Databáze: | OpenAIRE |
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