LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
| Autor: | Nino Sincic, Ana Katusic Bojanac, Floriana Bulic-Jakus, Dajana Krsnik, Tihana Maric |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Male
Spermatogonia / metabolism Aging Organic Chemistry Fertility / genetics General Medicine Catalysis Spermatogonia Computer Science Applications Testis / metabolism Inorganic Chemistry Fertility Klinefelter Syndrome Testicular Neoplasms LIN28A LIN28B cancer infertility testis Aging / genetics Testis Humans Testicular Neoplasms / metabolism Physical and Theoretical Chemistry Klinefelter Syndrome / metabolism Molecular Biology Spectroscopy |
| Zdroj: | International journal of molecular sciences. 23(13) |
| ISSN: | 1422-0067 |
| Popis: | Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents. |
| Databáze: | OpenAIRE |
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