Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study

Autor: Stinus Hansen, Niklas Rye Jørgensen, Kim Brixen, Katrine Diemer Frederiksen, Jeppe Gram, René Klinkby Støving, Stine Hanson, Vikram Vinod Shanbhogue
Rok vydání: 2017
Předmět:
Leptin
Male
Parathyroid Hormone/metabolism
Peptide Fragments/metabolism
Vitamin D/analogs & derivatives
0301 basic medicine
Bone density
Gastric Bypass/adverse effects
Endocrinology
Diabetes and Metabolism
Osteoporosis
Postoperative Complications/diagnostic imaging
Peptides/metabolism
medicine.disease_cause
Bone remodeling
Postoperative Complications
Absorptiometry
Photon
0302 clinical medicine
Endocrinology
Radius/diagnostic imaging
Bone Density
Weight loss
Insulin
Longitudinal Studies
Vitamin D
Bone Diseases
Metabolic/diagnostic imaging
Bone mineral
Lumbar Vertebrae
Follicle Stimulating Hormone/metabolism
Tibia/diagnostic imaging
General Medicine
Middle Aged
Obesity
Morbid
Radius
Adiponectin/metabolism
Parathyroid Hormone
Hip Joint
Female
Adiponectin
Bone Remodeling
Luteinizing Hormone/metabolism
medicine.symptom
Procollagen
Adult
medicine.medical_specialty
Insulin/metabolism
Lumbar Vertebrae/diagnostic imaging
Gastric Bypass
Urology
030209 endocrinology & metabolism
Collagen Type I/metabolism
Obesity
Morbid/surgery
Collagen Type I
Metabolic bone disease
03 medical and health sciences
Hip Joint/diagnostic imaging
Internal medicine
Weight Loss
Journal Article
medicine
Humans
Tibia
Osteoporosis/diagnostic imaging
Gastric bypass surgery
business.industry
Leptin/metabolism
Luteinizing Hormone
medicine.disease
Peptide Fragments
Procollagen/metabolism
Surgery
Bone Diseases
Metabolic
030104 developmental biology
Clinical Study
Follicle Stimulating Hormone
Peptides
Tomography
X-Ray Computed
business
Zdroj: Shanbhogue, V V, Støving, R K, Frederiksen, K H, Hanson, S, Brixen, K, Gram, J, Jørgensen, N R & Hansen, S 2017, ' Bone structural changes after gastric bypass surgery evaluated by HR-pQCT : a two-year longitudinal study ', European Journal of Endocrinology, vol. 176, no. 6, pp. 685-693 . https://doi.org/10.1530/EJE-17-0014
Shanbhogue, V V, Støving, R K, Frederiksen, K D, Hanson, S, Brixen, K, Gram, J, Jorgensen, N R & Hansen, S 2017, ' Bone structural changes after gastric bypass surgery evaluated by HR-pQCT : a two-year longitudinal study ', European Journal of Endocrinology, vol. 176, no. 6, pp. 685-693 . https://doi.org/10.1530/EJE-17-0014
European Journal of Endocrinology
ISSN: 1479-683X
0804-4643
DOI: 10.1530/eje-17-0014
Popis: Objective, design and methods Roux-en-Y gastric bypass (RYGB) has proved successful in attaining sustained weight loss but may lead to metabolic bone disease. To assess impact on bone mass and structure, we measured a real bone mineral density at the hip and spine by dual-energy X-ray absorptiometry, and volumetric BMD (vBMD) and bone microarchitecture at the distal radius and tibia by high-resolution peripheral quantitative CT in 25 morbidly obese subjects (15 females, 10 males) at 0, 12 and 24 months after RYGB. Bone turnover markers (BTMs), calciotropic and gut hormones and adipokines were measured at the same time points. Results After a 24.1% mean weight loss from baseline to month 12 (P P = 0.50). However, cortical and trabecular vBMD and microarchitecture deteriorated through the 24 months, such that there was a 5 and 7% reduction in estimated bone strength at the radius and tibia respectively (both P Conclusions Despite weight stabilization and maintenance of metabolic parameters, bone loss and deterioration in bone strength continued and were substantial in the second year. The clinical importance of these changes in terms of increased risk of developing osteoporosis and fragility fractures remain an important concern.
Databáze: OpenAIRE
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