Dynamic Nuclear Polarization of β-Cyclodextrin Macromolecules
| Autor: | Marta Filibian, Filippo Caracciolo, Pietro Carretta, Lucio Melone |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin Chemistry Doping Analytical chemistry 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Polarization (waves) 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films Amorphous solid Dilution Relaxation rate Chemical physics Thermal Materials Chemistry Physical and Theoretical Chemistry 0210 nano-technology Macromolecule |
| Zdroj: | The Journal of Physical Chemistry B. 121:2584-2593 |
| ISSN: | 1520-5207 1520-6106 |
| Popis: | 1H dynamic nuclear polarization and nuclear spin-lattice relaxation rates have been studied in amorphous complexes of β-cyclodextrins doped with different concentrations of the TEMPO radical. Nuclear polarization increased up to 10% in the optimal case, with a behavior of the buildup rate (1/TPOL) and of the nuclear spin-lattice relaxation rate (1/T1n) consistent with a thermal mixing regime. The temperature dependence of 1/T1n and its increase with the radical concentration indicate a relaxation process arising from the modulation of the electron–nucleus coupling by the glassy dynamics. The high-temperature relaxation is driven by molecular motions, and 1/T1n was studied at room temperature in liquid solutions for dilution levels close to the ones typically used for in vivo studies. |
| Databáze: | OpenAIRE |
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