Gephebase, a database of genotype–phenotype relationships for natural and domesticated variation in Eukaryotes
| Autor: | Arnaud Martin, Laurent Arnoult, Séverine Wiltgen, Stéphane R. Prigent, Virginie Courtier-Orgogozo |
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| Přispěvatelé: | Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), CNRS, Populations, Génétique et Evolution |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Candidate gene Databases Factual Genetic Linkage ved/biology.organism_classification_rank.species Biology computer.software_genre 010603 evolutionary biology 01 natural sciences User-Computer Interface 03 medical and health sciences Genetic linkage Databases Genetic Computer Graphics Genetics Database Issue Animals Humans Allele Model organism Association mapping Domestication Gene Alleles Genetic Association Studies 030304 developmental biology 2. Zero hunger Internet 0303 health sciences Database Human evolutionary genetics ved/biology [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] Chromosome Mapping Computational Biology Eukaryota Phenotype [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics Drosophila melanogaster Mutation DNA Transposable Elements Candidate Disease Gene computer Algorithms Software |
| Zdroj: | Nucleic Acids Research Nucleic Acids Research, Oxford University Press, 2019, ⟨10.1093/nar/gkz796⟩ |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkz796 |
| Popis: | Gephebase is a manually-curated database compiling our accumulated knowledge of the genes and mutations that underlie natural, domesticated and experimental phenotypic variation in all Eukaryotes — mostly animals, plants and yeasts. Gephebase aims to compile studies where the genotype-phenotype association (based on linkage mapping, association mapping or a candidate gene approach) is relatively well supported or understood. Human disease and aberrant mutant phenotypes in laboratory model organisms are not included in Gephebase and can be found in other databases (eg. OMIM, OMIA, Monarch Initiative). Gephebase contains more than 1700 entries. Each entry corresponds to an allelic difference at a given gene and its associated phenotypic change(s) between two species or between two individuals of the same species, and is enriched with molecular details, taxonomic information, and bibliographic information. Users can easily browse entries for their topic of interest and perform searches at various levels, whether phenotypic, genetic, taxonomic or bibliographic (eg. transposable elements, cis-regulatory mutations, snakes, carotenoid content, an author name). Data can be searched using keywords and boolean operators and is exportable in spreadsheet format. This database allows to perform meta-analysis to extract general information and global trends about evolution, genetics, and the field of evolutionary genetics itself. Gephebase should also help breeders, conservationists and others to identify the most promising target genes for traits of interest, with potential applications such as crop improvement, parasite and pest control, bioconservation, and genetic diagnostic. It is freely available at www.gephebase.org. |
| Databáze: | OpenAIRE |
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