Antitumor-promoting activities of hydrolyzable tannins in mouse skin
| Autor: | Jan M. Johnson, Elisabeth M. Perchellet, Darren S. Klish, Hala U. Gali, Jean-Pierre Perchellet |
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| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
Skin Neoplasms Antineoplastic Agents Tumor initiation Pharmacology Ornithine Decarboxylase medicine.disease_cause Mice chemistry.chemical_compound Tannic acid Animals Medicine Gallic acid Anticarcinogen Papilloma integumentary system DNA synthesis business.industry Carcinoma Hydrogen Peroxide General Medicine Hydrolyzable Tannins chemistry Biochemistry Enzyme Induction Tetradecanoylphorbol Acetate Female Tumor promotion business Carcinogenesis Ellagic acid |
| Zdroj: | Carcinogenesis. 13:715-718 |
| ISSN: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/13.4.715 |
| Popis: | Ellagic acid and gallic acid and its derivatives, applied topically to female CF-1 mice 20 min before each 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment inhibit the inductions of epidermal ornithine decarboxylase activity, hydroperoxide production and DNA synthesis caused by this potent tumor promoter in relation with their abilities to inhibit the promotion of skin papillomas and carcinomas in the two-step initiation-promotion protocol. Because of its potency against TPA promotion, tannic acid, which is already known to inhibit tumor initiation, may inhibit the multistage process of carcinogenesis. |
| Databáze: | OpenAIRE |
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