Association of human herpes, papilloma and polyoma virus families with bladder cancer
| Autor: | Panagiotakis G, Ismini Lasithiotaki, Danae Papadogianni, Demetrios A. Spandidos, Dimitrios Delakas, Maria N. Chatziioannou |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty viruses Biology Real-Time Polymerase Chain Reaction medicine.disease_cause Polymerase Chain Reaction Virus Biopsy medicine Humans Papillomaviridae Herpesviridae Aged Aged 80 and over Bladder cancer medicine.diagnostic_test Varicella zoster virus virus diseases Cancer General Medicine Middle Aged medicine.disease Virology Cell Transformation Neoplastic Real-time polymerase chain reaction Urinary Bladder Neoplasms DNA Viral Papilloma Female Polyomavirus Nested polymerase chain reaction |
| Zdroj: | Tumor Biology. 34:71-79 |
| ISSN: | 1423-0380 1010-4283 |
| Popis: | The aim of the present study was to assess the possible etiologic role of human papillomavirus (HPV), human herpes virus (HHV) and the human polyoma virus families (BKV and JCV) in the tumourigenesis of bladder cancer. Thirty biopsy specimens from patients with different grades and stages of bladder cancer, who underwent transurethral bladder cancer resection, and 30 normal bladder mucosa specimens were analysed using polymerase chain reaction (PCR) for the detection of the above three virus family members. The presence of HPV was determined in all specimens with nested PCR and real-time quantitative PCR. All cancerous specimens, including the control group, were found to be negative both by PCR and real-time qPCR for the presence of HPV DNA, whilst all samples examined by PCR tested negative for the presence of HSV-1,2 Varicella zoster virus and HSV-7 DNA. Cytomegalovirus, HHV-6 and HHV-8 exhibited similar incidence in sample positivity in both cancerous and healthy tissues. EBV showed a higher prevalence in bladder cancer specimens compared to healthy tissue (p = 0.048), whilst BKV and JCV were detected only in tumour samples. The presence of EBV in a significant proportion of bladder tumours indicates the etiological role of this virus in cancer tumourigenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink