Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy

Autor: Yu Shi, Zhengliang Zhang, Hai Wang, Zheng-Hai Bai, Jiangli Sun, Honghong Pei, Jun-Hua Lv
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Critical Illness
continuous renal replacement therapy
030232 urology & nephrology
body mass index
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
urologic and male genital diseases
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Renal replacement therapy
Hospital Mortality
Risk factor
Aged
Retrospective Studies
Aged
80 and over
urogenital system
business.industry
Critically ill
28-day mortality
Acute kidney injury
General Medicine
Middle Aged
Protective Factors
medicine.disease
Diseases of the genitourinary system. Urology
acute kidney injury
Nephrology
Clinical Study
Female
RC870-923
business
28 day mortality
Body mass index
Glomerular Filtration Rate
Zdroj: Renal Failure, Vol 41, Iss 1, Pp 726-732 (2019)
Renal Failure
ISSN: 1525-6049
Popis: Background: Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is a fatal and common clinical disorder in critically ill patients. Recent studies have shown that the relationship between BMI and the outcome of patients with AKI undergoing CRRT is conflicting. Methods: A retrospective cohort study based on data reuse. Univariate analysis, multi-factor regression analysis and subgroup analyses were used to explore the association of the BMI with the 28-days mortality risk in patients with AKI undergoing CRRT. Results: From January 2009 to September 2016, a total of 1120 cases met the inclusion criteria and were enrolled in this study. The univariate analysis showed that BMI was associated with 28-days mortality of patients with AKI undergoing CRRT, its HR value was 0.98 (0.96, 0.99). The multi-factor regression analysis showed that BMI was not associated with 28-days mortality of patients with AKI undergoing CRRT in the four models, the adjusted HR value of four models were 1.00 (0.96, 1.04), 1.01 (0.97, 1.04), 1.00 (0.96, 1.04) and 1.00 (0.96, 1.04), respectively. The subgroups analyses showed that the BMI was a risk factor of the 28-days mortality in patients with AKI undergoing CRRT when GFR ≥30 mL/min, its HR value was 1.04 (1.01, 1.09). Conclusion: Higher BMI was not a protective risk of 28-day mortality in patients with AKI undergoing CRRT. Especially, when GFR ≥30 mL/min, higher BMI increased the risk of the 28-day mortality rate in patients with AKI undergoing CRRT.
Databáze: OpenAIRE
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